Transcriptional Complexity

As part of the FANTOM (Functional Annotation of Mouse) Consortium, we have focused on cataloguing the transcriptional output of every locus and predicting the functional consequences of alternative splice junctions, transcription start sites and termination/polyad enylation sites.

Our group has used bioinformatics to review the scale and consequences of transcriptional complexity of signal transduction (the phosphoregulator network and extracellular space). Splice array profiling, capped analysis of gene expression (CAGE) and other massive scale sequencing approaches to confirm expression of these variants in biological processes and pathological states.

These studies are being refined for both mouse and human transcriptomes in collaboration with the Genome Network Project.

We are actively pursuing the role of the lesser characterised components of the transcriptome such as profiling and computationally screening transcripts of unknown function fo r small open reading frames and modelling and microRNA-target interactions.